Gene

According to Wikipedia, a gene is the basic unit of heredity in a living organism. The field of genetics predates modern molecular biology, but it is now known that all living things depend on DNA to pass on their traits to offspring. Loosely speaking, a gene is a segment of genomic information that, taken as a whole, specifies a trait. The colloquial usage of the term gene often refers to the scientific concept of an allele. The notion of a gene has evolved with the science of genetics, which began when Gregor Mendel noticed that biological variations were only inherited from parent organisms as specific, discrete traits. For example, if one parent has blue eyes and the other has brown eyes, there is a 3/4 chance that the child will have brown eyes. The biological entity responsible for defining eye color was termed a "gene", but the biological basis for inheritance remained unknown until the discovery of the genetic code in mid 1950s, when genes were determined to be encoded by DNA. All organisms have many genes corresponding to many different biological traits, some of which are immediately visible, such as eye color or number of limbs, and some of which are not, such as blood type or increased risk for certain diseases, or the thousands of basic biochemical processes which comprise life. In cells, a gene is a portion of an organism's DNA which contains both "coding" sequences that determine what the gene does, and "non-coding" sequences that determine when the gene is active (expressed.) When a gene is active, the coding and non-coding sequences are copied in a process called transcription, producing an RNA copy of the gene's information. This piece of RNA can then direct the synthesis of proteins via the genetic code. In other cases, the RNA is used directly, for example as part of the ribosome. The RNA may undergo special post-transcriptional processing steps required to convert it into a mature, functional form. These molecules resulting from gene expression, whether RNA or protein, are known as gene products, and are responsible for the development and functioning of all living things. More technically, a gene is a locatable region of genomic sequence, corresponding to a unit of inheritance, and is associated with regulatory regions, transcribed regions and/or other functional sequence regions. The physical development and phenotype of organisms can be thought of as a product of genes interacting with each other and with the environment. A concise definition of a gene, taking into account complex patterns of regulation and transcription, genic conservation and non-coding RNA genes, has been proposed by Gerstein et al:"A gene is a union of genomic sequences encoding a coherent set of potentially overlapping functional products". Deoxyribonucleic acid (DNA) is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms and some viruses. The main role of DNA molecules is the long-term storage of information. DNA is often compared to a set of blueprints or a recipe, or a code, since it contains the instructions needed to construct other components of cells, such as proteins and RNA molecules. The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in regulating the use of this genetic information. Chemically, DNA consists of two long polymers of simple units called nucleotides, with backbones made of sugars and phosphate groups joined by ester bonds. These two strands run in opposite directions to each other and are therefore anti-parallel. Attached to each sugar is one of four types of molecules called bases. It is the sequence of these four bases along the backbone that encodes information. This information is read using the genetic code, which specifies the sequence of the amino acids within proteins. The code is read by copying stretches of DNA into the related nucleic acid RNA, in a process called transcription. Within cells, DNA is organized into structures called chromosomes. These chromosomes are duplicated before cells divide, in a process called DNA replication. Eukaryotic organisms (animals, plants, fungi, and protists) store their DNA inside the cell nucleus, while in prokaryotes (bacteria and archae) it is found in the cell's cytoplasm. Within the chromosomes, chromatin proteins such as histones compact and organize DNA. These compact structures guide the interactions between DNA and other proteins, helping control which parts of the DNA are transcribed. The vast majority of living organisms encode their genes in long strands of DNA. DNA consists of a chain made from four types of nucleotide subunits: adenine, cytosine, guanine, and thymine. Each nucleotide subunit consists of three components: a phosphate group, a deoxyribose sugar ring, and a nucleobase. Thus, nucleotides in DNA or RNA are typically called 'bases'; consequently they are commonly referred to simply by their purine or pyrimidine original base components adenine, cytosine, guanine, thymine. Adenine and guanine are purines and cytosine and thymine are pyrimidines. The most common form of DNA in a cell is in a double helix structure, in which two individual DNA strands twist around each other in a right-handed spiral. In this structure, the base pairing rules specify that guanine pairs with cytosine and adenine pairs with thymine (each pair contains one purine and one pyrimidine). The base pairing between guanine and cytosine forms three hydrogen bonds, while the base pairing between adenine and thymine forms two hydrogen bonds. The two strands in a double helix must therefore be complementary, that is, their bases must align such that the adenines of one strand are paired with the thymines of the other strand, and so on. Due to the chemical composition of the pentose residues of the bases, DNA strands have directionality. One end of a DNA polymer contains an exposed hydroxyl group on the deoxyribose, this is known as the 3' end of the molecule. The other end contains an exposed phosphate group, this is the 5' end. The directionality of DNA is vitally important to many cellular processes, since double helices are necessarily directional (a strand running 5'-3' pairs with a complementary strand running 3'-5') and processes such as DNA replication occur in only one direction. All nucleic acid synthesis in a cell occurs in the 5'-3' direction, because new monomers are added via a dehydration reaction that uses the exposed 3' hydroxyl as a nucleophile. The expression of genes encoded in DNA begins by transcribing the gene into RNA, a second type of nucleic acid that is very similar to DNA, but whose monomers contain the sugar ribose rather than deoxyribose. RNA also contains the base uracil in place of thymine. RNA molecules are less stable than DNA and are typically single-stranded. Genes that encode proteins are composed of a series of three-nucleotide sequences called codons, which serve as the "words" in the genetic "language". The genetic code specifies the correspondence during protein translation between codons and amino acids. The genetic code is nearly the same for all known organisms.

Chromosome

Textbooks have often said that chromosomes were first observed in plant cells by a Swiss botanist named Karl Wilhelm von Nägeli in 1842. However, this opinion has been challenged, perhaps decisively, by Henry Harris, who has freshly reviewed the primary literature. In his opinion the claim of Nägeli to have seen spore mother cells divide is mistaken, as are some of his interpretations. Harris considers other candidates, especially Wilhelm Hofmeister, whose publications in 1848-9 include plates that definitely show mitotic events. Hofmeister was also the choice of Cyril Darlington. The work of other cytologists such as Walther Flemming, Eduard Strasburger, Otto Bütschli, Oskar Hertwig and Carl Rabl should be acknowledged. The use of basophilic aniline dyes was a new technique for effectively staining the chromatin material in the nucleus. Their behavior in animal (salamander) cells was later described in detail by Walther Flemming, who in 1882 "provided a superb summary of the state of the field." The name chromosome was invented in 1888 by Heinrich von Waldeyer. However, van Beneden's monograph of 1883 on the fertilised eggs of the parasitic roundworm Ascaris megalocephala was the outstanding work of this period. His conclusions are classic: Thus there is no fusion between the male chromatin and the female chromatin at any stage of division....The elements of male origin and those of female origin are never fused together in a cleavage nucleus, and perhaps they remain distinct in all the nuclei derived from them. [tranl: Harris p162] "It is not easy to identify who first discerned chromosomes during mitosis, but there is no doubt that those who first saw them had no idea of their significance... [but] with the work of Balbiani and van Beneden we move away from... the mechanism of cell division to a precise delineation of chromosomes and what they do during the division of the cell." Van Beneden's master work was closely followed by that of Carl Rabl, who reached similar conclusions. This more or less concludes the first period, in which chromosomes were visually sighted and the morphological stages of mitosis were described. Coleman also gives a useful review of these discoveries. Nucleus as the seat of heredity. The origin of this epoch-making idea lies in a few sentences tucked away in Ernst Haeckel's Generelle Morphologie of 1866. The evidence for this insight gradually accumulated until, after twenty or so years, two of the greatest in a line of great German scientists spelled out the concept. August Weismann proposed that the germ line is separate from the soma, and that the cell nucleus is the repository of the hereditary material, which, he proposed, is arranged along the chromosomes in a linear manner. Furthermore, he proposed that at fertilisation a new combination of chromosomes (and their hereditary material) would be formed. This was the explanation for the reduction division of meiosis (first described by van Beneden). Chromosomes as vectors of heredity. In a series of outstanding experiments, Theodor Boveri gave the definitive demonstration that chromosomes are the vectors of heredity. His two principles were: The continuity of chromosomesThe individuality of chromosomes. It was the second of these principles that was so original. Boveri was able to test the proposal put forward by Wilhelm Roux, that each chromosome carries a different genetic load, and showed that Roux was right. Upon the rediscovery of Mendel, Boveri was able to point out the connection between the rules of inheritance and the behaviour of the chromosomes. It is interesting to see that Boveri influenced two generations of American cytologists: Edmund Beecher Wilson, Walter Sutton and Theophilus Painter were all influenced by Boveri (Wilson and Painter actually worked with him). In his famous textbook The Cell, Wilson linked Boveri and Sutton together by the Boveri-Sutton theory. Mayr remarks that the theory was hotly contested by some famous geneticists: William Bateson, Wilhelm Johannsen, Richard Goldschmidt and T.H. Morgan, all of a rather dogmatic turn-of-mind. Eventually complete proof came from chromosome maps – in Morgan's own lab (Wikipedia ). So what is chromosome? Chromosome is A structure in all living cells that consists of a single molecule of DNA bonded to various proteins and that carries the genes determining heredity. In all eukaryotic cells, the chromosomes occur as threadlike strands in the nucleus. During cell reproduction, these strands coil up and condense into much thicker structures that are easily viewed under a microscope. Chromosomes occur in pairs in all of the cells of eukaryotes except the reproductive cells, which have one of each chromosome, and some red blood cells (such as those of mammals) that expel their nuclei. In bacterial cells and other prokaryotes, which have no nucleus, the chromosome is a circular strand of DNA located in the cytoplasm (According to http://dictionary.reference.com/). A chromosome is an organized structure of DNA and protein that is found in cells. A chromosome is a single piece of DNA that contains many genes, regulatory elements and other nucleotide sequences. Chromosomes also contain DNA-bound proteins, which serve to package the DNA and control its functions. The word chromosome comes from the Greek χρῶμα (chroma, color) and σῶμα (soma, body) due to their property of being stained very strongly by some dyes. Chromosomes vary extensively between different organisms. Chromosome is a very long DNA molecule and associated proteins, that carry portions of the hereditary information of an organism. A chromosome is formed from a single DNA molecule that contains many genes. A chromosomal DNA molecule contains three specific nucleotide sequences which are required for replication: a DNA replication origin; a centromere to attach the DNA to the mitotic spindle.; a telomere located at each end of the linear chromosome. The DNA molecule may be circular or linear, and can contain anything from 10,000 to 1,000,000,000 nucleotides in length. Typically eukaryotic cells (cells with nuclei) have large linear chromosomes and prokaryotic cells (cells without defined nuclei) have smaller circular chromosomes, although there are many exceptions to this rule. Furthermore, cells may contain more than one type of chromosome; for example, mitochondria in most eukaryotes and chloroplasts in plants have their own small chromosomes. In eukaryotes, nuclear chromosomes are packaged by proteins into a condensed structure called chromatin. This allows the very long DNA molecules to fit into the cell nucleus. The structure of chromosomes and chromatin varies through the cell cycle. Chromosomes may exist as either duplicated or unduplicated—unduplicated chromosomes are single linear strands, whereas duplicated chromosomes (copied during synthesis phase) contain two copies joined by a centromere. Compaction of the duplicated chromosomes during mitosis and meiosis results in the classic four-arm structure (pictured to the right). "Chromosome" is a rather loosely defined term. In prokaryotes, a small circular DNA molecule may be called either a plasmid or a small chromosome. These small circular genomes are also found in mitochondria and chloroplasts, reflecting their bacterial origins. The simplest chromosomes are found in viruses: these DNA or RNA molecules are short linear or circular chromosomes that often lack any structural proteins (Source: Wikipedia and http://www.accessexcellent.org/). From the other source (http://www.chromodisorder.org) explained that Chromosome is simply put. They discribed human cromosome that chromosomes are the structures that hold our genes. Genes are the individual instructions that tell our bodies how to develop and keep our bodies running healthy. In every cell of our body there are 20,000 to 25,000* genes that are located on 46 chromosomes. These 46 chromosomes occur as 23 pairs. We get one of each pair from our mother in the egg, and one of each pair from our father in the sperm. The first 22 pairs are labeled longest to shortest. The last pair are called the sex chromosomes labeled X or Y. Females have two X chromosomes (XX), and males have an X and a Y chromosome (XY). Therefore everyone should have 46 chromosomes in every cell of their body. If a chromosome or piece of a chromosome is missing or duplicated, there are missing or extra genes respectively. When a person has missing or extra information (genes) problems can develop for that individual's health and development. Each chromosomes has a p and q arm; p (petit) is the short arm and q (next letter in the alphabet) is the long arm. Some of the chromosomes like 13, 14, and 15 have very small p arms. When a karyotype is made (see below) the q arm is always put on the bottom and the p on the top. The arms are separated by a region known as the centromere (red in picture), which is a pinched area of the chromosome. The chromosomes need to be stained in order to see them with a microscope. When stained the chromosomes look like strings with light and dark 'bands'. Each chromosome arm is defined further by numbering the bands, the higher the number, the further that area is from the centromere.

All About Nucleus

NUCLEUS Nucleus is a membrane-enclosed organelle found in all eukaryotic cells. It contains most of the cell's genetic material, organized as multiple long linear DNA molecules in complex with a large variety of proteins, such as histones, to form chromosomes. The genes within these chromosomes are the cell's nuclear genome. The function of the nucleus is to maintain the integrity of these genes and to control the activities of the cell by regulating gene expression. The main structures making up the nucleus are the nuclear envelope, a double membrane that encloses the entire organelle and separates its contents from the cellular cytoplasm, and the nuclear lamina, a meshwork within the nucleus that adds mechanical support, much like the cytoskeleton supports the cell as a whole. Because the nuclear membrane is impermeable to most molecules, nuclear pores are required to allow movement of molecules across the envelope. These pores cross both of the membranes, providing a channel that allows free movement of small molecules and ions. The movement of larger molecules such as proteins is carefully controlled, and requires active transport regulated by carrier proteins. Nuclear transport is crucial to cell function, as movement through the pores is required for both gene expression and chromosomal maintenance. Although the interior of the nucleus does not contain any membrane-bound subcompartments, its contents are not uniform, and a number of subnuclear bodies exist, made up of unique proteins, RNA molecules, and particular parts of the chromosomes. The best known of these is the nucleolus, which is mainly involved in the assembly of ribosomes. After being produced in the nucleolus, ribosomes are exported to the cytoplasm where they translate mRNA (Wikipedia). The cell nucleus is a vast storehouse of biochemical information. It is the brain of the cell and the center for direction and coordination of the cell's metabolic and reproductive activities. The nucleus is the largest organelle of a cell. Cells with a nucleus are called eukaryotic cells becasue eukaryotic means, "possessing a true nucleus". Not all cells have nuclei. Plants and animals that we see all around us have nuclei. Organisms such as bacteria do not. The nucleus is about two to five micrometers long in diameter. It is surrounded by two membranes that form the nuclear envelope. This serves as a wall between messages and signals senty in and out of the nucleus. Most of the cell's genes are located in the nucleus. The nucleus contains DNA, RNA, a nucleoplasm, and a nucleolus.

There are three main types of instructions the nucleus does. The first is that it directs cellular reproduction, which basically means the cell divides into two new cells. The second is that the nucleus controls a cell's differentiation during the development of the metabolic activities of the cell. The third type of instruction of the nucelus is that it regulates the mtabolic activities of the cell.

The nucleus of a cell contains DNA with certain protiens that are arranged in long, thin threads called chromatic fibers. Those fibers coil into bodies called chromosomes during meosis. The DNA and RNA in the nucleus of the cell work together to build and control the cell. The hereditary information of the DNA is when transcribed into RNA, which serves as a messenger. That messenger then transports outside the nucleus through the nuclear pores to the ribosomes, where it guides the synthesis of proteins. The proteins produced by the nucleus are used as messages that the cell orders.

The two main parts of the nucleus are the nucleoplasm and the nucleolus. The nucleolus is usually visible as a dark, round spot in the nucleus. It helps in the formation of ribosomes. The nucleolus is made up of proteins and RNA. It is the site of ribosomal ribonucleic acud (rRNA) synthesis.

The cell nucleus is a vast storehouse of biochemical information. It is the brain of the cell and the center for direction and coordination of the cell's metabolic and reproductive activities. The nucleus is the largest organelle of a cell. Cells with a nucleus are called eukaryotic cells becasue eukaryotic means, "possessing a true nucleus". Not all cells have nuclei. Plants and animals that we see all around us have nuclei. Organisms such as bacteria do not. The nucleus is about two to five micrometers long in diameter. It is surrounded by two membranes that form the nuclear envelope. This serves as a wall between messages and signals senty in and out of the nucleus. Most of the cell's genes are located in the nucleus. The nucleus contains DNA, RNA, a nucleoplasm, and a nucleolus.

There are three main types of instructions the nucleus does. The first is that it directs cellular reproduction, which basically means the cell divides into two new cells. The second is that the nucleus controls a cell's differentiation during the development of the metabolic activities of the cell. The third type of instruction of the nucelus is that it regulates the mtabolic activities of the cell.

The nucleus of a cell contains DNA with certain protiens that are arranged in long, thin threads called chromatic fibers. Those fibers coil into bodies called chromosomes during meosis. The DNA and RNA in the nucleus of the cell work together to build and control the cell. The hereditary information of the DNA is when transcribed into RNA, which serves as a messenger. That messenger then transports outside the nucleus through the nuclear pores to the ribosomes, where it guides the synthesis of proteins. The proteins produced by the nucleus are used as messages that the cell orders.

The two main parts of the nucleus are the nucleoplasm and the nucleolus. The nucleolus is usually visible as a dark, round spot in the nucleus. It helps in the formation of ribosomes. The nucleolus is made up of proteins and RNA. It is the site of ribosomal ribonucleic acud (rRNA) synthesis.

(Cell Nucleus from http://www.fresno.k12.ca.us)

What's Cell??

The cell is Amazing. It is the structural and functional unit of all known living organism. The cell is one of the most basic units of life. There are cells that are organisms onto themselves, such as microscopic amoeba and bacteria cells. And there are cells that only function when part of a larger organism, such as the cells that make up your body.There are millions of different types of cells. It is the smallest unit of an organism that is classified as living, and is often called the building block of life. Some organisms, such as most bacteria, are unicellular (consist of a single cell). Other organisms, such as ostrich, are multicellular. (Humans have an estimated 100 trillion or 10¹⁴ cells; a typical cell size is 10 µm; a typical cell mass is 1 nanogram.) The largest known cell is an unfertilized ostrich egg cell.

In 1837 before the final cell theory was developed, a Czech Jan Evangelista Purkyně observed small "granules" while looking at the plant tissue through a microscope. The cell theory, first developed in 1839 by Matthias Jakob Schleiden and Theodor Schwann, states that all organisms are composed of one or more cells. All cells come from preexisting cells. Vital functions of an organism occur within cells, and all cells contain the hereditary information necessary for regulating cell functions and for transmitting information to the next generation of cells.

The word cell comes from the Latin cellula, meaning, a small room. The descriptive name for the smallest living biological structure was chosen by Robert Hooke in a book he published in 1665 when he compared the cork cells he saw through his microscope to the small rooms monks lived in (taken from Wikipedia). The cell is the smallest unit of life in our bodies. In the body, there are brain cells, skin cells, liver cells, stomach cells, and the list goes on. All of these cells have unique functions and features. And all have some recognizable similarities. All cells have a 'skin', called the plasma membrane, protecting it from the outside environment. The cell membrane regulates the movement of water, nutrients and wastes into and out of the cell. Inside of the cell membrane are the working parts of the cell. At the center of the cell is the cell nucleus. The cell nucleus contains the cell's DNA, the genetic code that coordinates protein synthesis. In addition to the nucleus, there are many organelles inside of the cell - small structures that help carry out the day-to-day operations of the cell. One important cellular organelle is the ribosome. Ribosomes participate in protein synthesis. The transciption phase of protein synthesis takes places in the cell nucleus. After this step is complete, the mRNA leaves the nucleus and travels to the cell's ribosomes, where translation occurs. Another important cellular organelle is the mitochondrion. Mitochondria (many mitochondrion) are often referred to as the power plants of the cell because many of the reactions that produce energy take place in mitochondria. Also important in the life of a cell are the lysosomes. Lysosomes are organelles that contain enzymes that aid in the digestion of nutrient molecules and other materials. Below is a labelled diagram of a cell to help you identify some of these structures. There are many different types of cells. One major difference in cells occurs between plant cells and animal cells. While both plant and animal cells contain the structures discussed above, plant cells have some additional specialized structures. Many animals have skeletons to give their body structure and support. Plants do not have a skeleton for support and yet plants don't just flop over in a big spongy mess. This is because of a unique cellular structure called the cell wall. The cell wall is a rigid structure outside of the cell membrane composed mainly of the polysaccharide cellulose. As pictured at left, the cell wall gives the plant cell a defined shape which helps support individual parts of plants. In addition to the cell wall, plant cells contain an organelle called the chloroplast (taken from :The Cell , Picture from http://it.pinellas.k12.fl.us/).

There are two types of cells: eukaryotic and prokaryotic. Prokaryotic cells are usually independent, while eukaryotic cells are often found in multicellular organisms (taken from Wikipedia).

Prokaryotic cells

Prokaryotes differ from eukaryotes since they lack a nuclear envelope and a cell nucleus. Prokaryotes also lack most of the intracellular organelles and structures that are seen in eukaryotic cells. There are two kinds of prokaryotes, bacteria and archaea, but these are similar in the overall structures of their cells. Most functions of organelles, such as mitochondria, chloroplasts, and the Golgi apparatus, are taken over by the prokaryotic cell's plasma membrane. Prokaryotic cells have three architectural regions: appendages called flagella and pili — proteins attached to the cell surface; a cell envelope - consisting of a capsule, a cell wall, and a plasma membrane; and a cytoplasmic region that contains the cell genom (DNA) and ribosomes and various sorts of inclusions.

Eukaryotic cells

Eukaryotic cells are about 10 times the size of a typical prokaryote and can be as much as 1000 times greater in volume. The major difference between prokaryotes and eukaryotes is that eukaryotic cells contain membrane-bound compartments in which specific metabolic activities take place. Most important among these is the presence of a cell nucleus, a membrane-delineated compartment that houses the eukaryotic cell's DNA. It is this nucleus that gives the eukaryote its name, which means "true nucleus." Diagram of a typical animal (eukaryotic) cell, showing subcellular components. Organelles: (1) nucleolus (2) nucleus (3) ribosome (4) vesicle (5) rough endoplasmic reticulum (ER) (6) Golgi apparatus (7) Cytoskeleton (8) smooth endoplasmic reticulum (9) mitochondria (10) vacuole (11) cytoplasm (12) lysosome (13) centrioles within centrosome

General Definition of Biology

Biology is the study of life and a branch of the natural science which studies living organisms and how they interact with each other and their environment. It examines the structure, function, growth, origin, evolution, and distribution of living things. Also, it classifies and describes organisms, their functions, and how species come into existence.

Other people described Biology as the science of life and of living organisms, including their structure, function, growth, origin, evolution, and distribution. It includes botany and zoology and all their subdivisions. And other give definition the science of life; that branch of knowledge which treats of living matter as distinct from matter which is not living; the study of living tissue. It has to do with the origin, structure, development, function, and distribution of animals and plants.

Biology as a separate science was developed in the nineteenth century as scientists discovered that organisms shared fundamental characteristics. Biology is now a standard subject of instruction at schools and universities around the world, and over a million papers are published annually in a wide array of biology and medicine journals.

Most biological sciences are specialized disciplines. Traditionally, they are grouped by the type of organism being studied: botany, the study of plants; zoology, the study of animals; and microbiology, the study of microorganisms. The fields within biology are further divided based on the scale at which organisms are studied and the methods used to study them: biochemistry examines the fundamental chemistry of life; molecular biology studies the complex interactions of systems of biological molecules; cellular biology examines the basic building block of all life, the cell; physiology examines the physical and chemical functions of the tissues and organ systems of an organism; and ecology examines how various organisms and their environment interrelate.

Biology is something interest because Biology is a basic knowledgement of our life. We life on earth with special think, human try to know how to heart work in our body. Sciencetist never tired to exploration about nature, about other organism, about base of life. You know the basic knowledgement to reach all above is Biology.

Let's Explore Your Life With Biology and make your nature be friendly if you know special secret of Biology.